Cryptic crossword clue
Spies awful southern corruption 6

The most common and most likely answer to this crossword clue is the 6 letter word SEPSIS

S
E
P
S
I
S


Buddy explains!

The straight part
We know that "corruption" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case corruption = sepsis.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEPSIS mean?

SEPSIS noun
  1. A serious medical condition in which the whole body is inflamed, causing injury to its own tissues and organs as a response to infection.

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