Cryptic crossword clue
Spike prankster’s drink 6

The most common and most likely answer to this crossword clue is the 6 letter word IMPALE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Spike" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spike = impale.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does IMPALE mean?

IMPALE verb
  1. To pierce (something) with any long, pointed object.
  2. To place two coats of arms side by side on the same shield (often those of two spouses upon marriage).
  3. To pierce with a pale; to put to death by fixing on a sharp stake.
  4. To enclose or fence with stakes.

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