The most common and most likely answer to this crossword clue is the 5 letter word PALSY
P
A
L
S
Y
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PALSY mean?
PALSY noun- Complete or partial muscle paralysis of a body part, often accompanied by a loss of feeling and uncontrolled body movements such as shaking.
- To paralyse, either completely or partially.
- Chummy, friendly.