The most common and most likely answer to this crossword clue is the 6 letter word PIMPLE
I've seen this crossword clue in The Daily Telegraph
P
I
M
P
L
E
More clues leading to the result PIMPLE
- Spot that's fairly quiet in big building
- Spot politician entering imposing building
- Spot politician going into mansion
- Spot sanctimonious politician with lingerie inside out
- Spot representative in stately home
- Spot politician entering a large building
- Spot politician in large building
- Spot politician in imposing building
- Spot politician in tall building
- Spot politician entering tall building
Buddy explains!

The straight part
We know that "Spot" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spot = pimple.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PIMPLE mean?
PIMPLE noun- An inflamed (raised and colored) spot on the surface of the skin that is usually painful and fills with pus.
- An annoying person.
- Scotch (whisky)
- To develop pimples