Cryptic crossword clue
Spots often associated with port wine or sparkling Évian 5

The most common and most likely answer to this crossword clue is the 5 letter word NAEVI

N
A
E
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I


Buddy explains!

The straight part
We know that "Spots often associated with port wine/S/pots often associated with port wine" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spots often associated with port wine/s/pots often associated with port wine = naevi.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NAEVI mean?

NAEVI noun
  1. A pigmented, raised or otherwise abnormal area on the skin. Naevi may be congenital or acquired, and are always benign.

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