The most common and most likely answer to this crossword clue is the 6 letter word STAINS
I've seen this crossword clue in The Daily Telegraph
S
T
A
I
N
S
More clues leading to the result STAINS
- Marks volunteers getting involved in crimes
- Marks & Spenser talk about introducing new stores initially
- Marks way by road from Edinburgh to London, north to south
- Location near Heathrow reported evidence of pollution
- Foxing well-known septet maybe interrupted by cheers
- Blemishes of holy folk? Time to come forward
- Dyes and cholesterol treatment avoid the heart
- . Splotches spoilt satin skirt at first
- Spots small containers keeping ale’s head
- Spots subs escaping outer reaches of Nimrod
Buddy explains!

The straight part
We know that "Spots" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spots = stains.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does STAINS mean?
STAINS noun- A discoloured spot or area.
- A blemish on one's character or reputation.
- A substance used to soak into a surface and colour it.
- A reagent or dye used to stain microscope specimens so as to make some structures visible.
- Any of a number of non-standard tinctures used in modern heraldry.
- To discolour.
- To taint or tarnish someone's character or reputation
- To coat a surface with a stain
- To become stained; to take a stain.
- To treat (a microscopic specimen) with a dye, especially one that dyes specific features
- To cause to seem inferior or soiled by comparison.