The most common and most likely answer to this crossword clue is the 6 plus 7 letter word BUTTER FINGERS
I've seen this crossword clue in The Guardian
B
U
T
T
E
R
F
I
N
G
E
R
S
Buddy explains!
The straight part
We know that "one who can’t hold it?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case one who can’t hold it? = butter fingers.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.