The most common and most likely answer to this crossword clue is the 5 letter word MARGE
I've seen this crossword clue in The Daily Telegraph
M
A
R
G
E
More clues leading to the result MARGE
- Mrs Simpson’s spread
- Spread stuff turning up on empty grave
- Spread betting finally grasped by horse
- Mrs Simpson‘s spread
- Woman uses 50% of butter substitutes
- Mrs Simpson‘s horse swallowing George’s crown!
- Spread of, say, strike rising
- Poetically speaking, not a centre spread
- Simpson is quite big after putting on new face
- Old charmer admits reading the better half of Homer
Buddy explains!

The straight part
We know that "Spread" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spread = marge.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MARGE mean?
MARGE noun- Margin; edge; verge.
- Margarine.