Cryptic crossword clue
Spurious blues tune almost without nuance

The most common and most likely answer to this crossword clue is the 8 letter word UNSUBTLE

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "without nuance" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case without nuance = unsubtle.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNSUBTLE mean?

UNSUBTLE adjective
  1. Not subtle; obvious

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