Cryptic crossword clue
Stag party, maybe, upset by female on the loose 5

The most common and most likely answer to this crossword clue is the 5 letter word FREED

I've seen this crossword clue in The Times
F
R
E
E
D

Buddy explains!

The straight part
We know that "on the loose" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case on the loose = freed.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FREED mean?

FREED verb
  1. To make free; set at liberty; release.
  2. To rid of something that confines or oppresses.

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