The most common and most likely answer to this crossword clue is the 4 plus 6 letter word EASY STREET
E
A
S
Y
S
T
R
E
E
T
More clues leading to the result EASY STREET
- English setter say barking in comfortable situation
- Bed of roses with trees, as yet to be replanted
- Relaxed with cryptic setter in secure comfort
- Relaxed, being on the road to a comfortable lifestyle
- Star, eyes rolling, appears in blockbuster film to attain comfortable affluence
- Life of Riley from undemanding cryptic setter
- English setter, say, barking in comfortable situation
- Simple way of affluent living
- English eccentric, say, acquires second plane? To a T, this describe his financial situation
- Yankee’s large plant in the Orient offers financial security
Buddy explains!

The straight part
We know that "comfortable affluence" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case comfortable affluence = easy street.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.