The most common and most likely answer to this crossword clue is the 4 plus 6 letter word TAKE OFFICE
T
A
K
E
O
F
F
I
C
E
Buddy explains!
The straight part
We know that "Start a new job" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case start a new job = take office.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.