Cryptic crossword clue
Start off being miserable and you’ll get the sack 8

The most common and most likely answer to this crossword clue is the 8 letter word EJECTION

I've seen this crossword clue in Financial Times
E
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Buddy explains!

The straight part
We know that "the sack" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the sack = ejection.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EJECTION mean?

EJECTION noun
  1. The act of ejecting.
  2. That which is ejected.

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