Cryptic crossword clue
Start off initially in drug trial with least sense 8

The most common and most likely answer to this crossword clue is the 8 letter word POTTIEST

I've seen this crossword clue in The Guardian
P
O
T
T
I
E
S
T

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POTTIEST mean?

POTTIEST adjective
  1. Insane.
  2. Easy to pot the ball on.

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