Cryptic crossword clue
State department leader obtained success by going against the flow 6

The most common and most likely answer to this crossword clue is the 6 letter word UPWIND

U
P
W
I
N
D

Buddy explains!

The straight part
We know that "going against the flow" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case going against the flow = upwind.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UPWIND mean?

UPWIND adjective
  1. Exposed to the wind
UPWIND adverb
  1. In the direction from which the wind is blowing
UPWIND verb
  1. To wind upwards.
  2. To wind up (a mechanism).

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