Cryptic crossword clue
State founder holds French here, confining infected — in need of this? 10

The most common and most likely answer to this crossword clue is the 10 letter word PENICILLIN

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Buddy explains!

The straight part
We know that "in need of this?" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in need of this? = penicillin.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PENICILLIN mean?

PENICILLIN noun
  1. Any of a group of narrow-spectrum antibiotics obtained from Penicillium molds or synthesized; they have a beta-lactam structure; most are active against gram-positive bacteria and used in the treatment of various infections and diseases.

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