Cryptic crossword clue
State has to work without leaders — that’s enough to make you mad 10

The most common and most likely answer to this crossword clue is the 10 letter word EXASPERATE

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Buddy explains!

The straight part
We know that "to make you mad" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to make you mad = exasperate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EXASPERATE mean?

EXASPERATE verb
  1. To tax the patience of, irk, frustrate, vex, provoke, annoy; to make angry.
EXASPERATE adjective
  1. Exasperated; embittered.

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