Cryptic crossword clue
State of agitation seeing return of s-spot 4

The most common and most likely answer to this crossword clue is the 4 letter word TIZZ

T
I
Z
Z

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The straight part
We know that "State of agitation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case state of agitation = tizz.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TIZZ mean?

TIZZ noun
  1. A tizzy; a state of worried confusion.

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