Cryptic crossword clue
State of calm required — agitated instead, gulping oxygen 8

The most common and most likely answer to this crossword clue is the 8 letter word SEDATION

S
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D
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The straight part
We know that "State of calm" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case state of calm = sedation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEDATION mean?

SEDATION noun
  1. The act of sedating, especially by use of sedatives.

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