Cryptic crossword clue
State parting two friends to a significant degree 10

The most common and most likely answer to this crossword clue is the 10 letter word MATERIALLY

I've seen this crossword clue in The Guardian
M
A
T
E
R
I
A
L
L
Y

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MATERIALLY mean?

MATERIALLY adverb
  1. In a material manner; with regard to physical things or characteristics.
  2. To a significant degree.

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