The most common and most likely answer to this crossword clue is the 6 letter word DISUSE
D
I
S
U
S
E
More clues leading to the result DISUSE
- Neglect exploit by detectives
- Neglect ache crossing South America
- Neglect daughter, one son gets help
- Neglect of French entertainer heartless
- Neglect to finish touring Dixie?
- Figure out filling to stop decay
- Fail to accept South American neglect
- Stop hiding South American neglect
- Police officer foolishly sues after neglect
- Fail to embrace South American neglect
Buddy explains!

The straight part
We know that "neglect" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case neglect = disuse.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DISUSE mean?
DISUSE noun- The state of not being used; neglect.
- To cease the use of.
- To disaccustom.