The most common and most likely answer to this crossword clue is the 6 letter word DESIST
I've seen this crossword clue in The Times
D
E
S
I
S
T
More clues leading to the result DESIST
- Stop somewhat rude sister
- Stop believer embracing saint
- Stop Des first!
- Stop one’s little boy going up on street
- Stop in dodgy side street
- Stop believer in God overshadowing saint
- Tides swirling round end of bus stop
- Stop moral type admitting sin, initially
- Stop in cobbled side street
- Stop tree being uprooted from shadowy side street
Buddy explains!

The straight part
We know that "Stop" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case stop = desist.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DESIST mean?
DESIST verb- To cease to proceed or act; to stop (often with from).