The most common and most likely answer to this crossword clue is the 11 letter word DESECRATION
I've seen this crossword clue in The Sunday Telegraph
D
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S
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C
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More clues leading to the result DESECRATION
Buddy explains!
The straight part
We know that "doing harm to something sacred" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case doing harm to something sacred = desecration.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DESECRATION mean?
DESECRATION noun- An act of disrespect or impiety towards something considered sacred.