Cryptic crossword clue
Strangely saturnine, neglecting US set 7

The most common and most likely answer to this crossword clue is the 7 letter word TRANNIE

I've seen this crossword clue in The Daily Telegraph
T
R
A
N
N
I
E

Buddy explains!

The straight part
We know that "set" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case set = trannie.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANNIE mean?

TRANNIE noun
  1. A transsexual, transgender or transvestite person, usually a trans woman.
  2. A transistor radio.
  3. A mechanical transmission, a gearbox.
  4. A transformer.
  5. A transition between moves.

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