The most common and most likely answer to this crossword clue is the 7 letter word EPHESUS
I've seen this crossword clue in The Daily Telegraph
E
P
H
E
S
U
S
More clues leading to the result EPHESUS
- Record suspicion about the man that’s ruined city
- Record man originally set by US city a while ago
- Recep? He’s ushered outside of ruined city
- Ancient city in European power, second among 12
- Kept these dust covers off ancient temple site
- Man’s breaking record us Greeks once established here
- Stray sheep seen by us in biblical city
- European tavern outwardly entices American in ancient city
- Revelations listed this church with humans behind mutilation of sheep
- Record american he’s in old city
Buddy explains!

The straight part
We know that "biblical city" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case biblical city = ephesus.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.