The most common and most likely answer to this crossword clue is the 6 plus 7 letter word COMBAT FATIGUE
C
O
M
B
A
T
F
A
T
I
G
U
E
Buddy explains!
The straight part
We know that "Stress from engagement" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case stress from engagement = combat fatigue.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.