Cryptic crossword clue
Study of waterworks beginning to help lady’s uric failing 10

The most common and most likely answer to this crossword clue is the 10 letter word HYDRAULICS

I've seen this crossword clue in Independent
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The straight part
We know that "Study of waterworks" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case study of waterworks = hydraulics.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HYDRAULICS mean?

HYDRAULICS noun
  1. The engineering science that deals with practical applications where liquid is in motion and transmits energy.
  2. The hydraulic system of a vehicle or other machine.

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