The most common and most likely answer to this crossword clue is the 6 letter word SPUTUM
I've seen this crossword clue in Financial Times
S
P
U
T
U
M
More clues leading to the result SPUTUM
- Something ejected from place included in total
- Deposit in total, what you’ll cough up
- Stuff coughed up when problem drinking plonk
- Something expressed or deposited in some amount
- Put in amount of phlegm
- Unpleasant stuff deposited in an amount of money
- Must strangely cover up the plutonium with phlegm
- Discharge from position during problem
Buddy explains!

The straight part
We know that "Stuff coughed up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case stuff coughed up = sputum.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SPUTUM mean?
SPUTUM noun- Matter coughed up and expectorated from the mouth, composed of saliva and discharges from the respiratory passages such as mucus, phlegm or pus.