The most common and most likely answer to this crossword clue is the 4 letter word MARC
I've seen this crossword clue in The Times
M
A
R
C
More clues leading to the result MARC
- Demonstrate putting away hot alcoholic drink
- Stuff to knock back? It’ll make you tiddly
- Refuse to shorten brisk walk
- Stuff knocked back is intoxicating stuff
- Remains after press pack has turned up
- Refuse to walk endlessly
- Type of brandy Republican kept in raincoat
- Spoil Charlie’s brandy
- Refuse to have gospel read out
- Stuff from down under is alcohol
Buddy explains!

The straight part
We know that "intoxicating stuff" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case intoxicating stuff = marc.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MARC mean?
MARC noun- The refuse matter that remains after fruit, particularly grapes, has been pressed.
- An alcoholic spirit distilled from the marc of grapes.
- A weight of various commodities, especially of gold and silver, used in different European countries. In France and Holland it was equal to eight ounces.
- A coin formerly current in England and Scotland, equal to thirteen shillings and four pence.
- A German coin and money of account; the mark.