Cryptic crossword clue
Stupid reply, ignoring wife at home alone at last 8

The most common and most likely answer to this crossword clue is the 8 letter word ANSERINE

I've seen this crossword clue in The Daily Telegraph
A
N
S
E
R
I
N
E

Buddy explains!

The straight part
We know that "Stupid" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case stupid = anserine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANSERINE mean?

ANSERINE adjective
  1. Silly, foolish, stupid.
  2. Pertaining to a goose or geese; gooselike.
ANSERINE noun
  1. A dipeptide compound present in birds and other vertebrates, originally isolated from goose muscle.

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