The most common and most likely answer to this crossword clue is the 9 letter word PLENTEOUS
I've seen this crossword clue in The Times
P
L
E
N
T
E
O
U
S
More clues leading to the result PLENTEOUS
- One lets up with changes abounding
- Substantial bonus opera company received, gathering in wings of theatre
- Being rich, one lets up foolishly
- Liberal gets benefit hosting the Department of Energy ball
- Ample soup served around holy time by priests at Centre
- Last couple in invite covered by ‘plus one’ possibly? More than sufficient
Buddy explains!

The straight part
We know that "Substantial" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case substantial = plenteous.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PLENTEOUS mean?
PLENTEOUS adjective- In plenty; abundant.
- Having plenty; abounding; rich.