Cryptic crossword clue
Sudden change for American humorist into small red jumper 10

The most common and most likely answer to this crossword clue is the 10 letter word SWITCHEROO

I've seen this crossword clue in The Times
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Buddy explains!

The straight part
We know that "Sudden change for American" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sudden change for american = switcheroo.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SWITCHEROO mean?

SWITCHEROO noun
  1. A sneaky, unexpected, or clever swap or exchange.
SWITCHEROO verb
  1. To swap or exchange surreptitiously.

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