Cryptic crossword clue
Suffering Syd in France very hardy in extremity with disease 9

The most common and most likely answer to this crossword clue is the 9 letter word DYSTROPHY

D
Y
S
T
R
O
P
H
Y

Buddy explains!

The straight part
We know that "disease" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case disease = dystrophy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DYSTROPHY mean?

DYSTROPHY noun
  1. A wasting of body tissues, of either genetic origin or due to inadequate or defective nutrition.

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