Cryptic crossword clue
Sugar-intolerant little girl has help with sick heart 8

The most common and most likely answer to this crossword clue is the 8 letter word DIABETIC

I've seen this crossword clue in The Guardian
D
I
A
B
E
T
I
C

Buddy explains!

The straight part
We know that "Sugar-intolerant" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sugar-intolerant = diabetic.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DIABETIC mean?

DIABETIC noun
  1. A person who suffers from diabetes mellitus.
DIABETIC adjective
  1. Of or pertaining to diabetes, especially diabetes mellitus.
  2. Having diabetes, especially diabetes mellitus.
  3. Suitable for one having diabetes mellitus.

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