Cryptic crossword clue
Supporters generally unpredictable, with following for Republican 6

The most common and most likely answer to this crossword clue is the 6 letter word FANDOM

I've seen this crossword clue in The Times
F
A
N
D
O
M

Buddy explains!

The straight part
We know that "Supporters generally" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case supporters generally = fandom.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FANDOM mean?

FANDOM noun
  1. The fans of a sport, activity, work, person etc., taken as a group.
  2. The subculture of fans.
  3. The state, quality, or condition of being a fan.

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