The most common and most likely answer to this crossword clue is the 12 letter word PROTAGONISTS
I've seen this crossword clue in Financial Times
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More clues leading to the result PROTAGONISTS
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PROTAGONISTS mean?
PROTAGONISTS noun- (authorship) The main character, or one of the main characters, in any story, such as a literary work or drama.
- A leading person in a contest; a principal performer.
- An advocate or champion of a cause or course of action.