Cryptic crossword clue
Supposed setback for De Niro, tackling ‘Page’ instead of ‘King’ 6

The most common and most likely answer to this crossword clue is the 6 letter word OPINED

I've seen this crossword clue in The Daily Telegraph
O
P
I
N
E
D

Buddy explains!

The straight part
We know that "Supposed" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case supposed = opined.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does OPINED mean?

OPINED verb
  1. To have or express an opinion; to state as an opinion; to suppose, consider (that).
  2. To give one's formal opinion (on or upon something).

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