Cryptic crossword clue
Supposedly having immunity, trendy former duke outflanks old copper 10

The most common and most likely answer to this crossword clue is the 10 letter word INOCULATED

I've seen this crossword clue in Independent
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does INOCULATED mean?

INOCULATED verb
  1. To introduce an antigenic substance or vaccine into something (e.g. the body) or someone, such as to produce immunity to a specific disease.
  2. (by extension) To safeguard or protect something as if by inoculation.
  3. To add one substance to another; to spike.
  4. To graft by inserting buds.
  5. To introduce into the mind (used especially of harmful ideas or principles); to imbue; to implant.

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