Cryptic crossword clue
Suppressing a pain, regret inflamed rear that’s used in cycling 10

The most common and most likely answer to this crossword clue is the 10 letter word DERAILLEUR

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Buddy explains!

The straight part
We know that "that’s used in cycling" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case that’s used in cycling = derailleur.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DERAILLEUR mean?

DERAILLEUR noun
  1. The mechanism on a bicycle used to move the chain from one sprocket (gear) to another.
  2. The entire gearset on a bicycle with such a mechanism.

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