The most common and most likely answer to this crossword clue is the 3 plus 7 letter word HOT FLUSHES
I've seen this crossword clue in The Guardian
H
O
T
F
L
U
S
H
E
S
More clues leading to the result HOT FLUSHES
Buddy explains!
The straight part
We know that "signs of discomfort in woman" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case signs of discomfort in woman = hot flushes.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.