Cryptic crossword clue
Sympathetic article penned by cardinal once 6

The most common and most likely answer to this crossword clue is the 6 letter word HUMANE

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "Sympathetic" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sympathetic = humane.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HUMANE mean?

HUMANE adjective
  1. (notcomp) Of or belonging to the species Homo sapiens or its closest relatives.
  2. Having the nature or attributes of a human being.
HUMANE adjective
  1. Having or showing concern for the pain or suffering of another; compassionate.
  2. Pertaining to branches of learning concerned with human affairs or the humanities, especially classical literature or rhetoric.

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