Cryptic crossword clue
Tabloids principally publish a lot of lies? 6

The most common and most likely answer to this crossword clue is the 6 letter word TISSUE

I've seen this crossword clue in Independent
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TISSUE mean?

TISSUE noun
  1. Thin, woven, gauze-like fabric.
  2. A fine transparent silk material, used for veils, etc.; specifically, cloth interwoven with gold or silver threads, or embossed with figures.
  3. A sheet of absorbent paper, especially one that is made to be used as tissue paper, toilet paper or a handkerchief.
  4. Absorbent paper as material.
  5. A group of cells similar in origin that function together to do a specific job.
  6. Web; texture; complicated fabrication; connected series.
TISSUE verb
  1. To form tissue of; to interweave.

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