Cryptic crossword clue
Tailored configuration for each issue with faulty Italian OS 15

The most common and most likely answer to this crossword clue is the 15 letter word PERSONALISATION

I've seen this crossword clue in The Guardian
P
E
R
S
O
N
A
L
I
S
A
T
I
O
N

Buddy explains!

The straight part
We know that "Tailored configuration/it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tailored configuration/it = personalisation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

PERSONALISATION noun
  1. The act of personalizing something, or adapting it for somebody's needs or tastes.
  2. The act of personifying; personification.

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