Cryptic crossword clue
Tainted comedian reformed, one coming out cleaned up 14

The most common and most likely answer to this crossword clue is the 14 letter word DECONTAMINATED

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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Crossword Answer definitions

DECONTAMINATED verb
  1. To remove contamination from (something), rendering it safe.

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