Cryptic crossword clue
Take something from Karachi, thereupon to this place 6

The most common and most likely answer to this crossword clue is the 6 letter word HITHER

H
I
T
H
E
R

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The straight part
We know that "to this place" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case to this place = hither.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HITHER mean?

HITHER adjective
  1. On this side; the nearer.
HITHER adverb
  1. To this place, to here.
  2. Over here

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