Cryptic crossword clue
Take the bite out of “Cool,” by director Lee 6

The most common and most likely answer to this crossword clue is the 6 letter word DEFANG

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Buddy explains!

The straight part
We know that "Take the bite out of" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case take the bite out of = defang.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEFANG mean?

DEFANG verb
  1. To remove the fangs from (something).
  2. To render harmless.

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