The most common and most likely answer to this crossword clue is the 7 letter word SAPIENT
I've seen this crossword clue in The Times
S
A
P
I
E
N
T
More clues leading to the result SAPIENT
- Panties off, very keen
- Fool that is not without heart may become wise
- Wise fool that is not heartless
- Silly ape isn't wise
- Taking food in hospital to suppress temperature is wise
- A letter gets mailed out? That’s wise
- Wise fool ignoring content of inane books
- Sage in fancy panties
- Wise getting pet in, as barking
- Wise to get panties off
Buddy explains!
The straight part
We know that "wise" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case wise = sapient.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SAPIENT mean?
SAPIENT noun- An intelligent, self-aware being.
- Attempting to appear wise or discerning.
- Possessing wisdom and discernment; wise, learned.
- Of a species or life-form, possessing intelligence or self-awareness.