Cryptic crossword clue
Taking small space off Sassenachs is a problem for horses 8

The most common and most likely answer to this crossword clue is the 8 letter word GLANDERS

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Buddy explains!

The straight part
We know that "a problem for horses" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case a problem for horses = glanders.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GLANDERS mean?

GLANDERS noun
  1. An infectious disease of horses, mules and donkeys caused by the bacterium Burkholderia, one species of which may be transmitted to humans.

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