Cryptic crossword clue
Talk with Jerry Seinfeld’s friend, “the Queen of her domain” 10

The most common and most likely answer to this crossword clue is the 10 letter word CHATELAINE

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Buddy explains!

The straight part
We know that "the Queen of her domain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case the queen of her domain = chatelaine.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does CHATELAINE mean?

CHATELAINE noun
  1. The mistress of a castle or large household.
  2. A chain or clasp worn at the waist by women with handkerchief, keys, etc., attached, supposed to resemble the chain of keys once worn by medieval chatelaines.
  3. A similar thing in miniature attached to a watchchain.

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