Cryptic crossword clue
Talked incoherently and is flushed following injection 8

The most common and most likely answer to this crossword clue is the 8 letter word JABBERED

I've seen this crossword clue in Financial Times
J
A
B
B
E
R
E
D

Buddy explains!

The straight part
We know that "Talked incoherently" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case talked incoherently = jabbered.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does JABBERED mean?

JABBERED verb
  1. To talk rapidly, indistinctly, or unintelligibly; to utter gibberish or nonsense.
  2. To utter rapidly or indistinctly; to gabble.

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